Guido Frank Pauli

Norman R. Farnsworth Professor of Pharmacognosy, Pharmaceutical Sciences
Associate Director, Institute for Tuberculosis Research
Director, Program for Collaborative Research in the Pharmaceutical Sciences

Contact

Building & Room:

414 PHARM

Address:

833 South Wood Street, Chicago, IL, 60612

Office Phone:

(312) 355-1949

Email:

gfp@uic.edu

Related Sites:

https://gfp.people.uic.edu/

Selected Publications

Simmler C, Graham JG, Chen S, Pauli GF. Integrated analytical assets aid botanical authenticity and adulteration management.. Fitoterapia. 2018;129:401-414. doi:10.1016/j.fitote.2017.11.017.

McAlpine JB, Chen S, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, Crimmins MT, Csete M, Dewapriya P, Egan JM, Garson MJ, Genta-Jouve G, Gerwick WH, Gross H, Harper MK, Hermanto P, Hook JM, Hunter L, Jeannerat D, Ji NY, Johnson TA, Kingston DGI , Koshino H, Lee HW, Lewin G, Li J, Linington RG, Liu M, McPhail KL, Molinski TF, Moore BS, Nam J, Neupane RP, Niemitz M, Nuzillard JM, Oberlies NH, Ocampos FMM , Pan G, Quinn RJ, Reddy DS, Renault JH, Rivera-Chávez J, Robien W, Saunders CM, Schmidt TJ, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo DJ, Verpoorte R, Wang BG, Williams CM, Williams PG, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin DC, Bisson J, Pauli GF. The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.. Natural Product Reports. 2018;. doi:10.1039/c7np00064b.

Choules MP, Klein L, Lankin DC, McAlpine JB, Cho S, Cheng J, Lee H, Suh JW, Jaki BU, Franzblau SG, Pauli GF. Residual Complexity Does Impact Organic Chemistry and Drug Discovery: The Case of Rufomyazine and Rufomycin.. The Journal of organic chemistry. 2018;83(12):6664-6672. doi:10.1021/acs.joc.8b00988.

Fan Q, Liu Y, Kulakowski D, Chen S, Friesen JB, Pauli GF, Song Q. Countercurrent separation assisted identification of two mammalian steroid hormones in Vitex negundo.. Journal of chromatography. A. 2018;1553:108-115. doi:10.1016/j.chroma.2018.04.033.

Liu Y, Zhang Y, Chen S, Friesen JB, Nikolić D, Choules MP, McAlpine JB, Lankin DC, Gemeinhart RA, Pauli GF. The influence of natural deep eutectic solvents on bioactive natural products: studying interactions between a hydrogel model and Schisandra chinensis metabolites.. Fitoterapia. 2018;127:212-219. doi:10.1016/j.fitote.2018.02.024.

Hajirahimkhan A, Mbachu OC, Simmler C, Ellis SG, Dong H, Nikolic DS, Lankin DC, van Breemen RB, Chen S, Pauli GF, Dietz BM, Bolton JL. Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication.. Journal of natural products. 2018;81(4):966-975. doi:10.1021/acs.jnatprod.7b01070.

Liu Y, Friesen JB, McAlpine JB, Lankin DC, Chen S, Pauli GF. Natural Deep Eutectic Solvents: Properties, Applications, and Perspectives.. Journal of natural products. 2018;81(3):679-690. doi:10.1021/acs.jnatprod.7b00945.

Allard PM, Bisson J, Azzollini A, Pauli GF, Cordell GA, Wolfender JL. Pharmacognosy in the digital era: shifting to contextualized metabolomics.. Current opinion in biotechnology. 2018;54:57-64. doi:10.1016/j.copbio.2018.02.010.

Phansalkar RS, Nam J, Chen S, McAlpine JB, Leme AA, Aydin B, Bedran-Russo AK, Pauli GF. Centrifugal partition chromatography enables selective enrichment of trimeric and tetrameric proanthocyanidins for biomaterial development.. Journal of chromatography. A. 2018;1535:55-62. doi:10.1016/j.chroma.2017.12.050.

Dunlap TL, Howell C, Mukand N, Chen S, Pauli GF, Dietz BM, Bolton JL. Red Clover Aryl Hydrocarbon Receptor (AhR) and Estrogen Receptor (ER) Agonists Enhance Genotoxic Estrogen Metabolism.. Chemical research in toxicology. 2017;30(11):2084-2092. doi:10.1021/acs.chemrestox.7b00237.

Li G, Simmler C, Chen L, Nikolic DS, Chen S, Pauli GF, van Breemen RB. Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2017;109:182-190. doi:10.1016/j.ejps.2017.07.034.

Keiler AM, Macejova D, Dietz BM, Bolton JL, Pauli GF, Chen S, van Breemen RB, Nikolic DS, Goerl F, Muders MH, Zierau O, Vollmer G. Evaluation of estrogenic potency of a standardized hops extract on mammary gland biology and on MNU-induced mammary tumor growth in rats.. The Journal of steroid biochemistry and molecular biology. 2017;174:234-241. doi:10.1016/j.jsbmb.2017.09.020.

Gao W, McAlpine JB, Choules MP, Napolitano JG, Lankin DC, Simmler C, Ho NA, Lee H, Suh JW, Burton IW, Cho S, Franzblau SG, Chen S, Pauli GF. Structural Sequencing of Oligopeptides Aided by ¹H Iterative Full-Spin Analysis.. Journal of natural products. 2017;80(10):2630-2643. doi:10.1021/acs.jnatprod.7b00207.

Friesen JB, McAlpine JB, Chen S, Pauli GF. (2017). The 9th International Countercurrent Chromatography Conference held at Dominican University, Chicago, USA, August 1-3, 2016.. Journal of chromatography. A. Vol. 1520. Page(s) 1-8.

Keiler AM, Helle J, Bader MI, Ehrhardt T, Nestler K, Kretzschmar G, Bernhardt R, Vollmer G, Nikolić D, Bolton JL, Pauli GF, Chen S, Dietz BM, van Breemen RB, Zierau O. A standardized Humulus lupulus (L.) ethanol extract partially prevents ovariectomy-induced bone loss in the rat without induction of adverse effects in the uterus.. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2017;34:50-58. doi:10.1016/j.phymed.2017.08.001.

Warit S, Rukseree K, Prammananan T, Hongmanee P, Billamas P, Jaitrong S, Chaiprasert A, Jaki BU, Pauli GF, Franzblau SG, Palittapongarnpim P. In Vitro Activities of Enantiopure and Racemic 1′-Acetoxychavicol Acetate against Clinical Isolates of Mycobacterium tuberculosis.. Scientia pharmaceutica. 2017;85(3). doi:10.3390/scipharm85030032.

Simmler C, Lankin DC, Nikolić D, van Breemen RB, Pauli GF. Isolation and structural characterization of dihydrobenzofuran congeners of licochalcone A.. Fitoterapia. 2017;121:6-15. doi:10.1016/j.fitote.2017.06.017.

Dietz BM, Chen S, Alvarenga RFR , Dong H, Nikolić D, Biendl M, van Breemen RB, Bolton JL, Pauli GF. DESIGNER Extracts as Tools to Balance Estrogenic and Chemopreventive Activities of Botanicals for Women’s Health.. Journal of natural products. 2017;80(8):2284-2294. doi:10.1021/acs.jnatprod.7b00284.

Melchor-Martínez EM, Silva-Mares DA, Torres-López E, Waksman-Minsky N, Pauli GF, Chen S, Niemitz M, Sánchez-Castellanos M, Toscano A, Cuevas G, Rivas-Galindo VM. Stereochemistry of a Second Riolozane and Other Diterpenoids from Jatropha dioica.. Journal of natural products. 2017;80(8):2252-2262. doi:10.1021/acs.jnatprod.7b00193.

Jaja-Chimedza A, Graf BL, Simmler C, Kim Y, Kuhn P, Pauli GF, Raskin I. Biochemical characterization and anti-inflammatory properties of an isothiocyanate-enriched moringa (Moringa oleifera) seed extract.. PloS one. 2017;12(8):e0182658. doi:10.1371/journal.pone.0182658.

Liu Y, Friesen JB, Grzelak E, Fan Q, Tang T, Durić K, Jaki BU, McAlpine JB, Franzblau SG, Chen S, Pauli GF. Sweet spot matching: A thin-layer chromatography-based countercurrent solvent system selection strategy.. Journal of chromatography. A. 2017;1504:46-54. doi:10.1016/j.chroma.2017.04.055.

AbouZid SF, Ahmed HS, Moawad AS, Owis AI, Chen S, Nachtergael A, McAlpine JB, Brent Friesen J, Pauli GF. Chemotaxonomic and biosynthetic relationships between flavonolignans produced by Silybum marianum populations.. Fitoterapia. 2017;119:175-184. doi:10.1016/j.fitote.2017.04.002.

Kulakowski D, Leme-Kraus AA, Nam J, McAlpine J, Chen S, Pauli GF, Ravindran S, Bedran-Russo AK. Oligomeric proanthocyanidins released from dentin induce regenerative dental pulp cell response.. Acta biomaterialia. 2017;55:262-270. doi:10.1016/j.actbio.2017.03.051.

Nelson KM, Dahlin JL, Bisson J, Graham JG, Pauli GF, Walters MA. Curcumin May (Not) Defy Science.. ACS medicinal chemistry letters. 2017;8(5):467-470. doi:10.1021/acsmedchemlett.7b00139.

Leme-Kraus AA, Aydin B, Vidal CM, Phansalkar RM, Nam J, McAlpine J, Pauli GF, Chen S, Bedran-Russo AK. Biostability of the Proanthocyanidins-Dentin Complex and Adhesion Studies.. Journal of dental research. 2017;96(4):406-412. doi:10.1177/0022034516680586.

Phansalkar RS, Simmler C, Bisson J, Chen S, Lankin DC, McAlpine JB, Niemitz M, Pauli GF. Evolution of Quantitative Measures in NMR: Quantum Mechanical qHNMR Advances Chemical Standardization of a Red Clover (Trifolium pratense) Extract.. Journal of natural products. 2017;80(3):634-647. doi:10.1021/acs.jnatprod.6b00923.

Nelson KM, Dahlin JL, Bisson J, Graham JG, Pauli GF, Walters MA. The Essential Medicinal Chemistry of Curcumin.. Journal of medicinal chemistry. 2017;60(5):1620-1637. doi:10.1021/acs.jmedchem.6b00975.

Gao W, Napolitano JG, Lankin DC, Kim JY, Jin YY, Lee H, Suh JW, Chen S, Pauli GF. Computer-assisted ¹ H NMR analysis of the anti-tuberculosis drug lead ecumicin.. Magnetic resonance in chemistry : MRC. 2017;55(3):239-244. doi:10.1002/mrc.4425.

Kim GE, Leme-Kraus AA, Phansalkar RS, Viana G, Wu C, Chen S, Pauli GF, Bedran-Russo A. Effect of Bioactive Primers on Bacterial-Induced Secondary Caries at the Tooth-Resin Interface.. Operative dentistry. 2017;42(2):196-202. doi:10.2341/16-107-L.

Nam J, Phansalkar RS, Lankin DC, McAlpine JB, Leme-Kraus AA, Vidal CM, Gan LS, Bedran-Russo A, Chen S, Pauli GF. Absolute Configuration of Native Oligomeric Proanthocyanidins with Dentin Biomodification Potency.. The Journal of organic chemistry. 2017;82(3):1316-1329. doi:10.1021/acs.joc.6b02161.

Bisson J, Simmler C, Chen S, Friesen JB, Lankin DC, McAlpine JB, Pauli GF. Dissemination of original NMR data enhances reproducibility and integrity in chemical research.. Natural product reports. 2016;33(9):1028-33. doi:10.1039/c6np00022c.

Wang S, Dunlap TL, Howell C, Mbachu OC, Rue E, Phansalkar RS, Chen S, Pauli GF, Dietz BM, Bolton JL. Hop (Humulus lupulus L.) Extract and 6-Prenylnaringenin Induce P450 1A1 Catalyzed Estrogen 2-Hydroxylation.. Chemical research in toxicology. 2016;29(7):1142-50. doi:10.1021/acs.chemrestox.6b00112.

Liu Y, Garzon JA, Friesen JB, Zhang Y, McAlpine JB, Lankin DC, Chen S, Pauli GF. Countercurrent assisted quantitative recovery of metabolites from plant-associated natural deep eutectic solvents.. Fitoterapia. 2016;112:30-37. doi:10.1016/j.fitote.2016.04.019.

AbouZid SF, Chen S, McAlpine JB, Friesen JB, Pauli GF. Silybum marianum pericarp yields enhanced silymarin products.. Fitoterapia. 2016;112:136-43. doi:10.1016/j.fitote.2016.05.012.

AbouZid SF, Chen S, Pauli GF. Silymarin content in Silybum marianum populations growing in Egypt.. Industrial crops and products. 2016;83:729-737. doi:10.1016/j.indcrop.2015.12.012.

Grzelak E, Hwang C, Cai G, Nam J, Choules MP, Gao W, Lankin DC, McAlpine JB, Mulugeta SG, Napolitano JG, Suh JW, Yang SH, Cheng J, Lee H, Kim JY, Cho S, Pauli GF, Franzblau SG, Jaki BU. Bioautography with TLC-MS/NMR for Rapid Discovery of Anti-tuberculosis Lead Compounds from Natural Sources.. ACS infectious diseases. 2016;2(4):294-301. doi:10.1021/acsinfecdis.5b00150.

Imai A, Lankin DC, Nikolić D, Ahn S, van Breemen RB, Farnsworth NR, McAlpine JB, Chen S, Pauli GF. Cycloartane Triterpenes from the Aerial Parts of Actaea racemosa.. Journal of natural products. 2016;79(3):541-54. doi:10.1021/acs.jnatprod.5b00927.

Bisson J, McAlpine JB, Friesen JB, Chen S, Graham JG, Pauli GF. Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?. Journal of medicinal chemistry. 2016;59(5):1671-90. doi:10.1021/acs.jmedchem.5b01009.

Pauli GF, Niemitz M, Bisson J, Lodewyk MW, Soldi C, Shaw JT, Tantillo DJ, Saya JM, Vos K, Kleinnijenhuis RA, Hiemstra H, Chen S, McAlpine JB, Lankin DC, Friesen JB. Toward Structural Correctness: Aquatolide and the Importance of 1D Proton NMR FID Archiving.. The Journal of organic chemistry. 2016;81(3):878-89. doi:10.1021/acs.joc.5b02456.

Simmler C, Kulakowski D, Lankin DC, McAlpine JB, Chen S, Pauli GF. Holistic Analysis Enhances the Description of Metabolic Complexity in Dietary Natural Products.. Advances in nutrition (Bethesda, Md.). 2016;7(1):179-89.

Liu Y, Friesen JB, Klein L, McAlpine JB, Lankin DC, Pauli GF, Chen S. The Generally Useful Estimate of Solvent Systems (GUESS) method enables the rapid purification of methylpyridoxine regioisomers by countercurrent chromatography.. Journal of chromatography. A. 2015;1426:248-51. doi:10.1016/j.chroma.2015.11.046.

Pauli GF, Chen S, Simmler C, Lankin DC, Gödecke T, Jaki BU, Friesen JB, McAlpine JB, Napolitano JG. (2015). Correction to Importance of Purity Evaluation and the Potential of Quantitative (1)H NMR as a Purity Assay.. Journal of medicinal chemistry. Vol. 58. Issue 22. Page(s) 9061.

Hajirahimkhan A, Simmler C, Dong H, Lantvit DD, Li G, Chen S, Nikolic DS, Pauli GF, van Breemen RB, Dietz BM, Bolton JL. Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women’s Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.. Chemical research in toxicology. 2015;28(11):2130-41. doi:10.1021/acs.chemrestox.5b00310.

Hajirahimkhan A, Simmler C, Dong H, Lantvit DD, Li G, Chen SS, Nikolic DF, Pauli GB, van Breemen RM, Dietz BL, Bolton J. Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women’s Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.. Chemical research in toxicology. 2015;28(11):2130-41. doi:10.1021/acs.chemrestox.5b00310.

Liu Y, Friesen JB, McAlpine JB, Pauli GF. Solvent System Selection Strategies in Countercurrent Separation.. Planta medica. 2015;81(17):1582-91. doi:10.1055/s-0035-1546246.

Simmler C, Anderson JR, Gauthier LL, Lankin DC, McAlpine JB, Chen S, Pauli GF. Metabolite Profiling and Classification of DNA-Authenticated Licorice Botanicals.. Journal of natural products. 2015;78(8):2007-22. doi:10.1021/acs.jnatprod.5b00342.

Dunlap TL, Wang S, Simmler C, Chen S, Pauli GF, Dietz BM, Bolton JL. Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It.. Chemical research in toxicology. 2015;28(8):1584-94. doi:10.1021/acs.chemrestox.5b00157.

Nam J, Phansalkar RS, Lankin DC, Bisson J, McAlpine JB, Leme AA, Vidal CM, Ramirez B, Niemitz M, Bedran-Russo A, Chen S, Pauli GF. Subtle Chemical Shifts Explain the NMR Fingerprints of Oligomeric Proanthocyanidins with High Dentin Biomodification Potency.. The Journal of organic chemistry. 2015;80(15):7495-507. doi:10.1021/acs.joc.5b01082.

Friesen JB, McAlpine JB, Chen S, Pauli GF. Countercurrent Separation of Natural Products: An Update.. Journal of natural products. 2015;78(7):1765-96. doi:10.1021/np501065h.

Pauli GF, Pro SM, Chadwick LR, Burdick T, Pro L, Friedl W, Novak N, Maltby J, Qiu F, Friesen JB. Real-Time Volumetric Phase Monitoring: Advancing Chemical Analysis by Countercurrent Separation.. Analytical chemistry. 2015;87(14):7418-25. doi:10.1021/acs.analchem.5b01613.

Napolitano JG, Simmler C, McAlpine JB, Lankin DC, Chen S, Pauli GF. Digital NMR profiles as building blocks: assembling ¹H fingerprints of steviol glycosides.. Journal of natural products. 2015;78(4):658-65. doi:10.1021/np5008203.

Phansalkar RS, Nam J, Chen S, McAlpine JB, Napolitano JG, Leme A, Vidal CM, Aguiar T, Bedran-Russo AK, Pauli GF. A galloylated dimeric proanthocyanidin from grape seed exhibits dentin biomodification potential.. Fitoterapia. 2015;101:169-78. doi:10.1016/j.fitote.2014.12.006.

Gao WY, Kim JR, Anderson J, Akopian TY, Hong SW, Jin YA, Kandror OY, Kim JG, Lee IH, Lee SM, Mulugeta SL, Sunoqrot SF, Wang YW, Yang SG, Yoon T, Goldberg A, Pauli G, Suh J, Franzblau S, Cho S. The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo.. Antimicrobial agents and chemotherapy. 2015;59(2):880-9. doi:10.1128/AAC.04054-14.

Friesen JB, Ahmed S, Pauli GF. Qualitative and quantitative evaluation of solvent systems for countercurrent separation.. Journal of chromatography. A. 2015;1377:55-63. doi:10.1016/j.chroma.2014.11.085.

Nikolić D, Lankin DC, Cisowska T, Chen S, Pauli GF, van Breemen RB. Nitrogen-Containing Constituents of Black Cohosh: Chemistry, Structure Elucidation, and Biological Activities.. Recent advances in phytochemistry. 2015;45:31-75. doi:10.1007/978-3-319-20397-3_2.

Ramos Alvarenga RF, Friesen JB, Nikolic DS, Simmler C, Napolitano JG, van Breemen RB, Lankin DC, McAlpine JB, Pauli GF, Chen S. K-targeted metabolomic analysis extends chemical subtraction to DESIGNER extracts: selective depletion of extracts of hops (Humulus lupulus).. Journal of natural products. 2014;77(12):2595-604. doi:10.1021/np500376g.

Gao WY, Kim J, Chen S, Cho SU, Choi JY, Jaki BC, Jin YE, Lankin DY, Lee JG, Lee SG, Napolitano JW, Franzblau SF, Suh J, Pauli G. Discovery and characterization of the tuberculosis drug lead ecumicin.. Organic letters. 2014;16(23):6044-7. doi:10.1021/ol5026603.

Pauli GF, Chen S, Simmler C, Lankin DC, Gödecke TU, Jaki BB, Friesen JB, McAlpine JG, Napolitano J. Importance of purity evaluation and the potential of quantitative ¹H NMR as a purity assay.. Journal of medicinal chemistry. 2014;57(22):9220-31. doi:10.1021/jm500734a.

van Breemen RB, Yuan YP, Banuvar SF, Shulman L, Qiu XM, Alvarenga RL, Chen SF, Dietz BC, Bolton JS, Pauli G, Krause E, Viana M, Nikolic D. Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops.. Molecular nutrition & food research. 2014;58(10):1962-9. doi:10.1002/mnfr.201400245.

Simmler C, Nikolic DS, Lankin DC, Yu Y, Friesen JB, van Breemen RB, Lecomte AF, Le Quémener C, Audo G, Pauli G. Orthogonal Analysis Underscores the Relevance of Primary and Secondary Metabolites in Licorice.. Journal of natural products. 2014;77(8):1806-16. doi:10.1021/np5001945.

Simmler C, Nikolić DC, Lankin D, Yu YB, van Breemen RF, Lecomte A, Le Quémener C, Audo G, Pauli G. Orthogonal Analysis Underscores the Relevance of Primary and Secondary Metabolites in Licorice.. Journal of natural products. 2014;. doi:10.1021/np5001945.

Simmler C, Jones TR, Anderson JC, Nikolić DB, van Breemen RD, Soejarto D, Chen SF, Pauli G. Species-specific Standardisation of Licorice by Metabolomic Profiling of Flavanones and Chalcones.. Phytochemical analysis : PCA. 2014;25(4):378-88.

Simmler C, Jones TR, Anderson JS, Nikolic DB, van Breemen RD, Soejarto D, Chen SF, Pauli G. Species-specific Standardisation of Licorice by Metabolomic Profiling of Flavanones and Chalcones.. Phytochemical analysis : PCA. 2014;25(4):378-88.

Krause EC, Yuan Y, Hajirahimkhan A, Dong HM, Dietz BS, Nikolic DF, Pauli GL, Bolton JB, van Breemen R. Biological and chemical standardization of a hop (Humulus lupulus) botanical dietary supplement.. Biomedical chromatography : BMC. 2014;28(6):729-34. doi:10.1002/bmc.3177.

Schinkovitz AF, Kaur AG, Urban E, Zehl M, Páchniková G, Wang Y, Kretschmer N, Slaninová I, Pauli G, Franzblau S, Krupitza G, Bauer R, Kopp B. Cytotoxic constituents from Lobaria scrobiculata and a comparison of two bioassays for their evaluation.. Journal of natural products. 2014;77(4):1069-73. doi:10.1021/np4008574.

Ramos Alvarenga RF, Wan B, Inui TG, Franzblau SF, Pauli GU, Jaki B. Airborne antituberculosis activity of Eucalyptus citriodora essential oil.. Journal of natural products. 2014;77(3):603-10. doi:10.1021/np400872m.

Yuan Y, Qiu XG, Nikolić DF, Chen SB, Huang K, Li G, Pauli G, van Breemen R. Inhibition of human cytochrome P450 enzymes by hops (Humulus lupulus) and hop prenylphenols.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2014;53:55-61. doi:10.1016/j.ejps.2013.12.003.

Elkington BG, Sydara KH, Newsome AC, Hwang C, Lankin DG, Simmler CG, Napolitano JF, Ree RG, Graham JD, Gyllenhaal C, Bouamanivong S, Souliya O, Pauli G, Franzblau S, Soejarto D. New finding of an anti-TB compound in the genus Marsypopetalum (Annonaceae) from a traditional herbal remedy of Laos.. Journal of ethnopharmacology. 2014;151(2):903-11. doi:10.1016/j.jep.2013.11.057.

Simmler C, Napolitano JG, McAlpine JB, Chen S, Pauli GF. Universal quantitative NMR analysis of complex natural samples.. Current opinion in biotechnology. 2014;25:51-9. doi:10.1016/j.copbio.2013.08.004.

Klein L, Petukhova V, Wan B, Wang YD, Santasiero BC, Lankin DF, Pauli GG, Franzblau S. A novel indigoid anti-tuberculosis agent.. Bioorganic & medicinal chemistry letters. 2014;24(1):268-70. doi:10.1016/j.bmcl.2013.11.024.

Dong SH, Cai GG, Napolitano JC, Nikolić DB, Lankin DD, van Breemen RF, Soejarto D, Pauli G, Chen S. Lipidated steroid saponins from Dioscorea villosa (wild yam).. Fitoterapia. 2013;91:113-24. doi:10.1016/j.fitote.2013.07.018.

Cai GG, Napolitano JU, Wang YW, Jaki BH, Suh JA, Yang SG, Lee IF, Franzblau S, Pauli G, Cho S. Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain.. Journal of natural products. 2013;76(11):2009-18. doi:10.1021/np400145u.

Simmler C, Fronczek FR, Pauli GF, Santarsiero BD. Absolute configuration of naturally occurring glabridin.. Acta crystallographica. Section C, Crystal structure communications. 2013;69(Pt 11):1212-6. doi:10.1107/S0108270113018842.

Hwang CH, Jaki BU, Klein L, Lankin DC, Napolitano JG, Fryling NA, Franzblau SG, Cho S, Stamets PE, Wang YF, Pauli G. Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis.. Journal of natural products. 2013;76(10):1916-22. doi:10.1021/np400497f.

Simmler C, Pauli GF, Chen S. Phytochemistry and biological properties of glabridin.. Fitoterapia. 2013;90:160-84. doi:10.1016/j.fitote.2013.07.003.

Hajirahimkhan A, Simmler C, Yuan YR, Anderson J, Chen SM, Nikolić DF, Dietz BB, Pauli GL, van Breemen R, Bolton J. Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms.. PloS one. 2013;8(7):e67947. doi:10.1371/journal.pone.0067947.

Hajirahimkhan A, Simmler C, Yuan YR, Anderson J, Chen SS, Nikolic DM, Dietz BF, Pauli GB, van Breemen RL, Bolton J. Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms.. PloS one. 2013;8(7):e67947. doi:10.1371/journal.pone.0067947.

Dietz BM, Hagos GK, Eskra JN, Wijewickrama GT, Anderson JR, Nikolic DS, Guo JJ, Wright B, Chen SF, Pauli GB, van Breemen RL, Bolton J. Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo.. Molecular nutrition & food research. 2013;57(6):1055-66. doi:10.1002/mnfr.201200534.

Cai GF, Pauli GU, Wang YG, Jaki B, Franzblau S. Rapid determination of growth inhibition of Mycobacterium tuberculosis by GC-MS/MS quantitation of tuberculostearic acid.. Tuberculosis (Edinburgh, Scotland). 2013;93(3):322-9. doi:10.1016/j.tube.2012.12.004.

Qiu FU, Cai GC, Jaki BG, Lankin DF, Franzblau S, Pauli G. Quantitative purity-activity relationships of natural products: the case of anti-tuberculosis active triterpenes from Oplopanax horridus.. Journal of natural products. 2013;76(3):413-9. doi:10.1021/np3007809.

Simmler C, Hajirahimkhan A, Lankin DC, Bolton JL, Jones TD, Soejarto D, Chen SF, Pauli G. Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay.. Journal of agricultural and food chemistry. 2013;61(9):2146-57. doi:10.1021/jf304445p.

Dong SH, Nikolić D, Simmler CB, Qiu FD, van Breemen RF, Soejarto D, Pauli G, Chen S. Diarylheptanoids from Dioscorea villosa (Wild Yam).. Journal of natural products. 2012;75(12):2168-77. doi:10.1021/np300603z.

Dong SH, Nikolic DS, Simmler C, Qiu FB, van Breemen RD, Soejarto DF, Pauli G, Chen S. Diarylheptanoids from Dioscorea villosa (Wild Yam).. Journal of natural products. 2012;75(12):2168-77. doi:10.1021/np300603z.

Inui TM, Wang YG, Pro SF, Franzblau S, Pauli G. Unbiased evaluation of bioactive secondary metabolites in complex matrices.. Fitoterapia. 2012;83(7):1218-25. doi:10.1016/j.fitote.2012.06.012.

Nikolić D, Gödecke TC, Chen SF, White JB, Lankin D, Pauli G, van Breemen R. Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.).. Fitoterapia. 2012;83(3):441-60. doi:10.1016/j.fitote.2011.12.006.

Hemachandra LP, Madhubhani P, Chandrasena RC, Esala PA, Chen SM, Main MF, Lankin DR, Scism RL, Dietz B, Pauli G, Thatcher G, Bolton J. Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A).. Cancer prevention research (Philadelphia, Pa.). 2012;5(1):73-81. doi:10.1158/1940-6207.CAPR-11-0348.

Gödecke TG, Yao PM, Napolitano JL, Nikolić DB, Dietz BR, Bolton J, van Breemen RC, Farnsworth NF, Chen S, Lankin D, Pauli G. Integrated standardization concept for Angelica botanicals using quantitative NMR.. Fitoterapia. 2012;83(1):18-32. doi:10.1016/j.fitote.2011.08.017.

Li J, Gödecke TC, Chen SR, Imai AF, Lankin DB, Farnsworth N, Pauli G, van Breemen R, Nikolić D. In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4.. Xenobiotica; the fate of foreign compounds in biological systems. 2011;. doi:10.3109/00498254.2011.603385.

Chen S, Webster DS, Nikolic DB, van Breemen R, Wang ZH, Fong HR, Farnsworth NF, Pauli G. Phytoconstituents from Vitex agnus-castus fruits.. Fitoterapia. 2011;82(4):528-33. doi:10.1016/j.fitote.2010.12.003.

Choi YJ, Jermihov KR, Nam S, Sturdy MD, Maloney KR, Qiu XF, Chadwick LM, Main MB, Chen S, Mesecar A, Farnsworth N, Pauli G, Fenical W, Pezzuto J, van Breemen R. Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS.. Analytical chemistry. 2011;83(3):1048-52. doi:10.1021/ac1028424.

Inui TS, Wang YC, Nikolic DG, Smith DF, Franzblau S, Pauli G. Sesquiterpenes from Oplopanax horridus.. Journal of natural products. 2010;73(4):563-7. doi:10.1021/np900674d.

Scher JM, Schinkovitz AG, Zapp JC, Wang YF, Franzblau S, Becker H, Lankin D, Pauli G. Structure and anti-TB activity of trachylobanes from the liverwort Jungermannia exsertifolia ssp. cordifolia.. Journal of natural products. 2010;73(4):656-63. doi:10.1021/np900806j.

Aponte JC, Vaisberg AJ, Castillo DH, Gonzalez GM, Estevez YL, Arevalo JG, Quiliano MF, Zimic MB, Verástegui M, Málaga E, Gilman R, Bustamante J, Tarleton R, Wang Y, Franzblau S, Pauli G, Sauvain M, Hammond G. Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines.. Bioorganic & medicinal chemistry. 2010;18(8):2880-6. doi:10.1016/j.bmc.2010.03.018.

van Breemen RB, Liang WP, Banuvar S, Shulman LS, Pang YM, Tao Y, Nikolic DL, Krock KF, Chen SE, Hedayat SC, Bolton JE, Pauli GR, Piersen C, Krause E, Geller S, Farnsworth N. Pharmacokinetics of 23-epi-26-deoxyactein in women after oral administration of a standardized extract of black cohosh.. Clinical pharmacology and therapeutics. 2010;87(2):219-25. doi:10.1038/clpt.2009.251.

Geller SE, Shulman LP, van Breemen RB, Banuvar SS, Zhou YC, Epstein GE, Hedayat SL, Nikolic DF, Krause ER, Piersen C, Bolton J, Pauli G, Farnsworth N. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial.. Menopause (New York, N.Y.). 2009;16(6):1156-66. doi:10.1097/gme.0b013e3181ace49b.

Gödecke TC, Lankin DS, Nikolic D, Chen SB, van Breemen RR, Farnsworth NF, Pauli G. Guanidine alkaloids and Pictet-Spengler adducts from black cohosh (Cimicifuga racemosa).. Journal of natural products. 2009;72(3):433-7. doi:10.1021/np8006952.

Gödecke TS, Nikolic DC, Lankin D, Chen SL, Powell SM, Dietz BL, Bolton JB, van Breemen RR, Farnsworth NF, Pauli G. Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts.. Phytochemical analysis : PCA. 2009;20(2):120-33. doi:10.1002/pca.1106.

Powell SL, Gödecke TS, Nikolic D, Chen SM, Ahn SR, Dietz BB, Farnsworth NC, van Breemen RF, Lankin DL, Pauli G, Bolton J. In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent.. Journal of agricultural and food chemistry. 2008;56(24):11718-26. doi:10.1021/jf803298z.

Overk CR, Guo JR, Chadwick LD, Lantvit D, Minassi AC, Appendino GR, Chen SF, Lankin DB, Farnsworth NL, Pauli G, van Breemen R, Bolton J. In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin.. Chemico-biological interactions. 2008;176(1):30-9. doi:10.1016/j.cbi.2008.06.005.

Dietz BM, Liu DK, Hagos GM, Yao PR, Schinkovitz AF, Pro SB, Deng SL, Farnsworth N, Pauli G, van Breemen R, Bolton J. Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1.. Chemical research in toxicology. 2008;21(10):1939-48. doi:10.1021/tx8001274.

Yuan H, He RF, Wan BG, Wang YP, Pauli G, Franzblau S, Kozikowski A. Modification of the side chain of micromolide, an anti-tuberculosis natural product.. Bioorganic & medicinal chemistry letters. 2008;18(19):5311-5. doi:10.1016/j.bmcl.2008.08.027.

Jaki BU, Franzblau SG, Chadwick LR, Lankin DC, Zhang FF, Wang Y, Pauli G. Purity-activity relationships of natural products: the case of anti-TB active ursolic acid.. Journal of natural products. 2008;71(10):1742-8. doi:10.1021/np800329j.

Deng S, Wang YR, Inui T, Chen SG, Farnsworth NF, Cho S, Franzblau S, Pauli G. Anti-TB polyynes from the roots of Angelica sinensis.. Phytotherapy research : PTR. 2008;22(7):878-82. doi:10.1002/ptr.2303.

Overk CR, Yao P, Chen SR, Deng SF, Imai AL, Main M, Schinkovitz A, Farnsworth N, Pauli G, Bolton J. High-content screening and mechanism-based evaluation of estrogenic botanical extracts.. Combinatorial chemistry & high throughput screening. 2008;11(4):283-93.

Chen S, Turner AU, Jaki BS, Nikolic DB, van Breemen RF, Pauli G. An experimental implementation of chemical subtraction.. Journal of pharmaceutical and biomedical analysis. 2008;46(4):692-8. doi:10.1016/j.jpba.2007.12.014.

Farnsworth NR, Krause EC, Bolton JL, Pauli GF, van Breemen RB, Graham JG. The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research for Women’s Health: from plant to clinical use.. The American journal of clinical nutrition. 2008;87(2):504S-8S.

Pang Y, Nikolic DS, Zhu DR, Chadwick LF, Pauli GR, Farnsworth NB, van Breemen R. Binding of the hop (Humulus lupulus L.) chalcone xanthohumol to cytosolic proteins in Caco-2 intestinal epithelial cells.. Molecular nutrition & food research. 2007;51(7):872-9. doi:10.1002/mnfr.200600252.

Case RJ, Wang YG, Franzblau SD, Soejarto DF, Matainaho L, Piskaut P, Pauli G. Advanced applications of counter-current chromatography in the isolation of anti-tuberculosis constituents from Dracaena angustifolia.. Journal of chromatography. A. 2007;1151(1-2):169-74. doi:10.1016/j.chroma.2007.01.022.

Chen S, Lankin DC, Nikolic DS, Lu ZZ, Ramirez BB, van Breemen RH, Fong HR, Farnsworth NF, Pauli G. Chlorination diversifies Cimicifuga racemosa triterpene glycosides.. Journal of natural products. 2007;70(6):1016-23. doi:10.1021/np0700319.

Inui TC, Wang YG, Deng SF, Smith D, Franzblau S, Pauli G. Counter-current chromatography based analysis of synergy in an anti-tuberculosis ethnobotanical.. Journal of chromatography. A. 2007;1151(1-2):211-5. doi:10.1016/j.chroma.2007.01.127.

Cho S, Warit S, Wan BH, Hwang CF, Pauli GG, Franzblau S. Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis.. Antimicrobial agents and chemotherapy. 2007;51(4):1380-5. doi:10.1128/AAC.00055-06.

Deng S, Chen S, Lu JS, Wang ZB, Nikolic DD, van Breemen RH, Santarsiero BR, Mesecar AF, Fong H, Farnsworth N, Pauli G. GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels.. Phytochemical analysis : PCA. 2006;17(6):398-405.

Guo JS, Nikolic DR, Chadwick LF, Pauli GB, van Breemen R. Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.).. Drug metabolism and disposition: the biological fate of chemicals. 2006;34(7):1152-9. doi:10.1124/dmd.105.008250.

Case RJ, Franzblau SG, Wang Y, Cho SD, Soejarto DF, Pauli G. Ethnopharmacological evaluation of the informant consensus model on anti-tuberculosis claims among the Manus.. Journal of ethnopharmacology. 2006;106(1):82-9. doi:10.1016/j.jep.2005.12.005.

Jaki BU, Franzblau SG, Cho S, Pauli GF. Development of an extraction method for mycobacterial metabolome analysis.. Journal of pharmaceutical and biomedical analysis. 2006;41(1):196-200. doi:10.1016/j.jpba.2005.10.022.

Deng S, Chen SS, Yao PB, Nikolic DL, van Breemen RH, Bolton JR, Fong HF, Farnsworth N, Pauli G. Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis.. Journal of natural products. 2006;69(4):536-41. doi:10.1021/np050301s.

Booth NL, Overk CR, Yao PE, Burdette JS, Nikolic D, Chen SL, Bolton JB, van Breemen RF, Pauli GR, Farnsworth N. The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract.. Journal of alternative and complementary medicine (New York, N.Y.). 2006;12(2):133-9. doi:10.1089/acm.2006.12.133.

Booth NL, Overk CR, Yao PS, Totura SL, Deng YF, Hedayat AR, Bolton J, Pauli G, Farnsworth N. Seasonal variation of red clover (Trifolium pratense L., Fabaceae) isoflavones and estrogenic activity.. Journal of agricultural and food chemistry. 2006;54(4):1277-82. doi:10.1021/jf052927u.

Pauli GF, Case RJ, Inui T, Wang YH, Cho SG, Fischer N, Franzblau S. New perspectives on natural products in TB drug research.. Life sciences. 2005;78(5):485-94. doi:10.1016/j.lfs.2005.09.004.

Overk CR, Yao PR, Chadwick LS, Nikolic DK, Ajayi OA, Cuendet MS, Deng YF, Hedayat AR, Pauli GB, Farnsworth NL, van Breemen R, Bolton J. Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense).. Journal of agricultural and food chemistry. 2005;53(16):6246-53. doi:10.1021/jf050448p.

Nikolic DS, Lankin DC, Chen S, Jaki BU, Krunic A, van Breemen RB, Fong HH, Farnsworth NR, Pauli GF. Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa.. Journal of natural products. 2005;68(8):1266-70. doi:10.1021/np050066d.

Dietz BM, Kang YH, Liu GL, Eggler AR, Yao PF, Chadwick LR, Pauli GD, Farnsworth NB, Mesecar AL, van Breemen R, Bolton J. Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase.. Chemical research in toxicology. 2005;18(8):1296-305. doi:10.1021/tx050058x.

Ma CJ, Case RJ, Wang YT, Zhang HM, Tan GG, Van Hung ND, Cuong NH, Franzblau SF, Soejarto D, Fong H, Pauli G. Anti-tuberculosis constituents from the stem bark of Micromelum hirsutum.. Planta medica. 2005;71(3):261-7. doi:10.1055/s-2005-837826.

Nikolic DS, Li YR, Chadwick LF, Pauli GB, van Breemen R. Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes.. Journal of mass spectrometry : JMS. 2005;40(3):289-99. doi:10.1002/jms.753.

Chadwick LR, Nikolic DS, Burdette JE, Overk CR, Bolton JL, van Breemen RB, Fröhlich RH, Fong HR, Farnsworth NF, Pauli G. Estrogens and congeners from spent hops (Humulus lupulus).. Journal of natural products. 2004;67(12):2024-32. doi:10.1021/np049783i.